Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 6 2 2009 06 15 12 15 M. Jahangirnezhad 1Associate Professor, Department of Periodontology, School of Dentistry, Ahwaz Jondishapour Universi 2015 10 03  Objective: Assessment of subgingival human cytomegalovirus (HCMV) and Epstein Barr virus (EBV-1) in subjects with aggressive periodontitis. Materials and Methods: Samples were obtained from plaques formed in subgingival regions of 26 aggressive periodontitis patients. All specimens were submitted to polymerase chain reaction in order to detect HCMV and EBV-1. Results: HCMV and EBV-1 were observed in 27% and 25% of the participants respectively. Coinfection with both viruses was found in 52% of the patients. Conclusion: Within the limitations of the present study, it can be suggested that HCMV and EBV-1 in subgingival plaques may be associated with aggressive periodontitis. Additionally, concomitant occurrence of these viruses may negatively affect the wellbeing of periodontal tissues https://fid.tums.ac.ir/index.php/fid/article/view/180 https://fid.tums.ac.ir/index.php/fid/article/download/180/180