Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 1 1 2004 03 15 15 20 Lotfazar M Amirghofran Z Nicfarjam L 2015 10 03 Statement of Problem: Papillon Lefevre syndrome (PLS) is a rate autosomal recessive disorder, which is characterized by palmar- plantar hyperkeratosis and rapid periodontal destruction of primary and permanent dentitions. Purpose: The aim of the present study was to evaluate the peripheral blood neutrophil function including random locomotion, chemotaxis and oxidative mechanism of killing in a group of patients with PLS. Materials and Methods: Peripheral blood was obtained from 8 PLS patients and 92 healthy control subjects. PMN mobility was measured by a modification of the micromethod of Addison and Babbage. Latex-Stimulated NBT reduction test described by Park et al was followed. Data were analyzed by Mann Whitney U test. Results: The chemotactic activity in the PLS group was significantly lower than control group (89.5±21.6 vs 113±16 m, P0.05). Conclusion: The present study indicated an impaired neutrophil chemotaxis in PLS patients. https://fid.tums.ac.ir/index.php/fid/article/view/2 https://fid.tums.ac.ir/index.php/fid/article/download/2/2