Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 15 6 2018 11 28 332 338 EN Nazanin Mortazavi Assistant Professor, Department of Oral and Maxillofacial Medicine, Dental School, Golestan University of Medical Sciences, Gorgan, Iran Dental Research Center, Golestan University of Medical Sciences, Gorgan, Iran Mansour Babaei Assistant Professor, Department of Rheumatology, Medical School, Babol University of Medical Sciences, Babol, Iran Neda Babaee Associate Professor, Department of Oral and Maxillofacial Medicine, Dental School, Babol University of Medical Sciences, Babol, Iran Hamed Hossein Kazemi Assistant Professor, Department of Oral and Maxillofacial Medicine, Dental School, Babol University of Medical Sciences, Babol, Iran Roozbeh Mortazavi Assistant Professor, Department of Internal Medicine, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran Amrollah Mostafazadeh Associate Professor, Department of Immunology and Serology, Medical School, Babol University of Medical Sciences, Babol, Iran 2017 12 15 2018 06 11 Objectives: Temporomandibular joint (TMJ) disorders, known as TMDs, are significant public health problems and may result in pain and disability. In order to determine the prevalence of clinical/subjective TMD in rheumatoid arthritis (RA), we used the research diagnostic criteria (RDC)/TMD axes. We assessed the anti-cyclic citrullinated protein (anti-CCP)-related TMD in RA for the first time.     Materials and Methods: Fifty-two RA patients were compared to 47 healthy controls with regard to complete blood count (CBC), serology, acute phase reactants (APR), and TMJ dysfunction.  Results: The anti-CCP antibody showed a significant correlation with the development of clinical TMD (P=0.001, 95% confidence interval (CI)=12.4%-35.6%). A prevalence of 50% was calculated through the RDC/TMD for such disorders. In RA patients, statistically significant differences were observed between the groups with and without clinical TMD regarding psychological depression and physical symptoms. Conclusions: According to the results, a significant correlation was found between the anti-CCP antibody and TMD. Therefore, when this antibody is detected in the blood serum, the treatment must be initiated. The RDC/TMD used in this study assessed the prevalence of TMJ dysfunction in conformity with RA-associated TMJ findings previously obtained through other conventional methods.     https://fid.tums.ac.ir/index.php/fid/article/view/2290