Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 16 2 2019 04 30 144 148 EN Ruchi Gulati Department of Periodontology, Government College of Dentistry, Madhya Pradesh, India Madhu Ratre Department of Periodontology, Government College of Dentistry, Madhya Pradesh, India Shaleen Khetarpal Department of Periodontology, Government College of Dentistry, Madhya Pradesh, India Manish Varma Department of Periodontology, Government College of Dentistry, Madhya Pradesh, India 2018 03 08 2018 10 25 The aim of the present report was to discuss a unique case of gingival plasma cell granuloma (PCG) in a hypertensive patient on Amlodipine therapy. Also, we attempt to emphasize the importance of considering primary and advance investigations before making a definite diagnosis. PCG is an extremely rare, reactive, non-neoplastic lesion characterized by the predominance of polyclonal plasma cells. Drug-induced gingival overgrowth is a known side effect of Amlodipine. A hypertensive 60-year-old female patient reported with a chief complaint of swollen gums and discomfort in the upper front teeth region. A provisional diagnosis of Amlodipine-induced gingival overgrowth, combined gingival overgrowth, and fibroma was suggested. Surprisingly, histopathology revealed it to be a plasma cell lesion which was confirmed by advanced investigations, thereby establishing a confirmatory diagnosis of PCG. https://fid.tums.ac.ir/index.php/fid/article/view/2440 https://fid.tums.ac.ir/index.php/fid/article/download/2440/1750