Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 17 0 2020 12 13 3333 3333 Azadeh Khajavi Department of Prosthodontics, School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran Shabnam Mohseni Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran Amir Peymani Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Mehrak Amjadi Department of Prosthodontics, Dental Caries Prevention Research Center, Qazvin University of Medical Sciences, Qazvin, Iran 2019 10 23 2020 08 31 Objectives: Bacterial leakage at the implant-abutment interface is one of the main causes of peri-implant inflammation. One of the factors that influences bacterial leakage is the structural design of the interface. Considering the limited studies that have examined slip-joint connections, a comparative study of bacterial leakage was performed on two different systems namely Zimmer (Tapered Screw-Vent, Zimmer Dental) with slip-joint connection and Argon (Konus K3pro, Argon Implants) with conical connection. Materials and Methods: Twenty-two implants were selected in 2 groups (11 Zimmer with slip-joint connection, and 11 Argon with conical connection) with similar platforms. Escherichia coli (E. coli) suspension (2 μL) was pipetted into the internal lumen of implants. The abutments were screwed onto the implants with a closing torque of 30 Ncm. The assemblies were placed in culture broth for 6, 24, 48 and 72 h, and 7 and 14 days. The colonies were counted and analyzed by the Mann-Whitney test (a=0.05). Results: Microleakage was observed in 20% of the samples of conical connection group after 6 h to 2 days, and in 50% of the samples in slip-joint connection group after 3 to 7 days. There was a significant difference in bacterial leakage rate between the two implant groups (P<0.001) but no significant difference was seen in bacterial leakage over time (P>0.05). Conclusion: Type of connection had a significant effect on bacterial leakage, but the rate of bacterial leakage did not significantly change over time. https://fid.tums.ac.ir/index.php/fid/article/view/3333 https://fid.tums.ac.ir/index.php/fid/article/download/3333/1827