Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 11 5 2014 10 15 604 9 Jaber Yaghini Assistant Professor, Department of Periodontics, Torabinejad Research Center, Esfahan University of Medical Sciences, Isfahan, Iran. Sima Kiani Postgraduate Student, Department of Periodontology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. Shiva Mortazavi Assistant Professor, Department of Pediatrics, Torabinejad Research Center, Esfahan University of Medical Sciences, Isfahan, Iran. Bahareh Haghshenas Dentist, Privet Practice, Iran. Ahmad Mogharehabed Associated Professor, Department of Periodontics, Torabinejad Research Center, Isfahan University of Medical Sciences, Esfahan, Iran. 2015 10 16 Presence of available and stable fluoride in a dentifrice formulation is a major requirement for an anti-caries effect. Although the available fluoride concentration in Iranian dentifrices has been reported in previous studies, there is little information on its stability; which is dependent upon dentifrice formulation. This study was done to assess the fluoride ion concentration and stability in four widely used dentifrices in Iran.In this analytical study, three samples of each brand of dentifrice (Nasim, Pooneh, Crest, and Signal) were purchased. Total fluoride (TF) and total soluble fluoride (TSF) concentrations were determined by ion specific electrodes. Data about TF were analyzed by one-way analysis of variance (ANOVA). Kruskal-Wallis and Mann-Whitney tests were used for nonparametric data (TSF).All dentifrices had more than 1000 ppm of fluoride ions. TSF in Crest was significantly higher than in other dentifrices (P https://fid.tums.ac.ir/index.php/fid/article/view/376 https://fid.tums.ac.ir/index.php/fid/article/download/376/352