Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 18 0 2022 01 01 3760 3760 EN Monir Moradzadeh Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Abbas Karimi Department of Oral and Maxillofacial Surgery, School of Dentistry; Craniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Hassan Mirmohammad Sadeghi Department of Oral & Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran Samira Derakhshan Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Seyed Mobin Tafreshi Private Practice, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Samar Jalali Private Practice, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran 2020 09 06 2021 07 11 Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed. https://fid.tums.ac.ir/index.php/fid/article/view/3760