Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 12 1 2015 02 15 11 7 Beheshteh Malekafzali Associate Professor, Department of Pediatric, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Maliheh Ekrami Post Graduate Student, Department of Operative, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Armin Mirfasihi Dental Student, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Zahra Abdolazimi Post Graduate Student, Department of Pediatric, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2015 10 16 Although fluoridated toothpastes are among the most accessible fluoride sources for caries prevention, their remineralization potential remains questionable. This study sought to compare the effects of 5 different child formula dentifrices on remineralization of artificial primary enamel caries using a pH cycling model.Twenty sound primary canine teeth were immersed in demineralizing solution for 96 hours to produce 100μm-deep artificial caries. The teeth were then longitudinally sectioned into 100-150 μm-thick slices and randomly divided into 5 groups and treated as follows: group A. Calcium phosphate toothpaste, group B. Pooneh children's toothpaste, group C. Biotin toothpaste, group D. Crest children's toothpaste and group E. Darougar children's toothpaste. The specimens underwent a pH cycling model for 10 days. The degree of demineralization before and after treatment and its changes were evaluated under a polarized light microscope and a stereomicroscope and data were statistically analyzed using repeated measures ANOVA and post-hoc test.Stereomicroscopic analysis showed that only group C had a significant difference with other groups (P0.05). Polarized light microscopic analysis revealed that in addition to group C, a significant difference was detected between groups A and B (P=0.02) and calcium phosphate toothpaste showed higher efficacy.All the understudy toothpastes had remineralizing effect but calcium phosphate children's toothpaste had the highest and biotin toothpaste had the lowest efficacy. https://fid.tums.ac.ir/index.php/fid/article/view/377 https://fid.tums.ac.ir/index.php/fid/article/download/377/353