Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 11 5 2014 10 15 516 22 Mahvash Moosavijazi Assistant Professor, Dental Research Center Dentistry Research Institute Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Amir Alireza Rasouli Ghahroudi Assistant Professor, Dental Research Center Dentistry Research Institute Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Siamak Yaghoobee Assistant Professor, Dental Research Center Dentistry Research Institute Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Mojtaba Bayani Postgraduate Student, Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Eisa Salehi Assistant Professor, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Roozbeh Sadrimanesh Prosthodontist, Private Practice, Tehran, Iran. 2015 10 16 Epidermal growth factor (EGF) is a polypeptide molecule, with important functions in epithelial growth and wound repair. It exerts its effects on cells by binding to receptors on the cell surface. The aim of this study was to evaluate and compare salivary EGF levels in patients with gingivitis and advanced periodontitis as well as in healthy controls.Unstimulated salivary samples were collected from patients with gingivitis and advanced periodontitis and healthy individuals. The clinical parameters of plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL) were measured and recorded using a Williams probe. The enzyme-linked immunosorbent assay (ELISA) was used to determine salivary levels of EGF. One-way ANOVA was used for data analysis.The mean salivary level of EGF in healthy individuals (99.27) was significantly higher than that in patients with gingivitis (61.53). This value in patients with gingivitis (61.53) was also significantly higher than that in subjects with periodontitis (36.14) (P https://fid.tums.ac.ir/index.php/fid/article/view/398 https://fid.tums.ac.ir/index.php/fid/article/download/398/374