Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 20 0 2023 05 02 1 6 Kumar Pawan Department of Prosthodontics and Implantology, SRM Dental College and Hospital, Chennai, India. Vasudevan Karthikeyan Department of Prosthodontics and Implantology, SRM Dental College and Hospital, Chennai, India Krishnan Murugesan Department of Prosthodontics and Implantology, SRM Dental College and Hospital, Chennai, India Balasubramaniam Muthukumar Department of Prosthodontics and Implantology, SRM Dental College and Hospital, Chennai, India Krishna Raja Department of Oral and Maxillofacial Surgery, SRM Dental College and Hospital, Chennai India. Sivanesan Jagdish Department of Prosthodontics and Implantology, Chettinad Dental College and Research Institute, Chennai India 2022 01 02 2022 10 09 This report details the successful prosthetic rehabilitation of a 25-year-old male patient with Papillon Lefèvre Syndrome (PLS) using an implant-supported hybrid prosthesis. Six implants were placed in the maxilla, and four were placed in the mandibular arch. All implants were inserted axially (non-tilted) and were planned to be loaded after a healing period of 6 months. One implant failed due to graft loss during the healing phase, which was removed and the remaining implants were restored with a hybrid prosthesis after 6 months, using the delayed loading protocol. The patient was followed-up for four years and all the remaining implants successfully integrated and remained fully functional during this period. The prosthesis significantly improved the functional, aesthetic, and psychological well-being of the patient. This case report is the first of its kind to use only four axially placed implants for rehabilitation of a PLS patient with a successful four-year follow-up. https://fid.tums.ac.ir/index.php/fid/article/view/4339