Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 11 4 2014 08 15 379 88 Sara Tavassoli-Hojjati Department of Pediatric Dentistry, Dental School, Shahed University, Tehran, Iran. Mohammad Atai Iran Polymer and Petrochemical Institute (IPPI), Tehran, Iran. Roza Haghgoo Department of Pediatric Dentistry, Dental School, Shahed University, Tehran, Iran. Sara Rahimian-Imam Department of Pediatric Dentistry, Dental School, Zahedan University of Medical Sciences, Zahedan, Iran. Somayeh Kameli Department of Pediatric Dentistry, Dental School, Shahed University, Tehran, Iran. Fatemeh Ahmaian-Babaki Department of Pediatric Dentistry, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Faezeh Hamzeh Department of Operative Dentistry, Dental School, Kerman University of Medical Sciences, Kerman, Iran. Maryam Ahmadyar Dental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2015 10 16 The aim of this study was to investigate the mechanical properties (flexural strength, micro-shear bond strength) and remineralizing potential of fissure sealants by adding various concentrations of β-tricalcium phosphate nanoparticles.This in-vitro study consisted of five experimental groups containing prepared nano-fisssure sealants (1-5 wt.% β-TCP nanoparticles) and two control groups containing a prepared and a commercial fissure sealant. Flexural/micro-shear bond strength values were measured using Zwick test machine. Cavities on sixty healthy premolar teeth were filled with the fissure sealants containing 0-5 wt.% of nano β-TCP. The samples were assessed for remineralization under scanning electron microscopy (SEM) and EDAX. Kolmogorov-Smirnov test, One-way ANOVA and Tukey's Post Hoc analysis/HSD were used to analyze the data.There was no significant difference between the flexural strengths/elastic modulus of the 0-5 wt.% nano β-TCP groups (p>0.05). The average flexural strength/elastic modulus of the prepared fissure sealant group (0%) was significantly higher than the commercial fissure sealant group (Clinpro) (p0.05). Examining the samples under SEM showed a significant increase in thickness of the intermediate layer with increasing concentrations of β-TCP nanoparticles (p https://fid.tums.ac.ir/index.php/fid/article/view/434 https://fid.tums.ac.ir/index.php/fid/article/download/434/410