Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 22 0 2025 07 27 4460 4460 Wael Zaatari . Department of Operative Dentistry and Endodontics, Faculty of Dental Medicine, Aleppo University, Aleppo, Syrian Arab Republic Mahmoud Tarakji Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Aleppo University, Aleppo, Syrian Arab Republic Helen Ayoubi Department of Operative Dentistry and Endodontics, Faculty of Dental Medicine, Damascus University, Damascus, Syrian Arab Republic 2022 05 04 2024 04 06 Dens in dente is an uncommon developmental tooth case called dens invaginatus or dilated odontoma, which originates through invagination of the enamel organ into the dental papilla, the most common tooth to occur dens in dente is maxillary lateral incisor. Dens in Dente is often accompanied by necrotic pulp and periapical lesion. Also, impacted teeth are one of the reasons for the odontogenic cysts and tumors. Dentigerous cyst one of the types of odontogenic cyst occurs in association with an unerupted tooth, most commonly mandibular third molars. Other common associations are with, maxillary canines, and mandibular second premolars. This report discusses dens in dente case in maxillary lateral incisor and impacted maxillary canine teeth with extended periodontitis and treatment it by combining with root canal treatment and surgical treatment. https://fid.tums.ac.ir/index.php/fid/article/view/4460 https://fid.tums.ac.ir/index.php/fid/article/download/4460/2153