Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 11 3 2014 06 15 290 301 Fahimeh Akhlaghi Associate Professor,, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Esmaeelinejad Resident, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Amin Shams Dental Researcher, Dental Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Arsalan Augend Private Practice, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahid Beheshti University of Medica Sciences, Tehran, Iran. 2015 10 16 Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity. This study aims to evaluate different treatment procedures including neo-adjuvant, concurrent and adjuvant therapy in treating squamous cell carcinoma of the head and neck by a meta-analysis.The authors searched all electronic databases (Medline, Embase and Cochrane) for all the articles published from 1970 to January 2011. Data of the evaluated treatment procedures (chemotherapy or radiotherapy), number of patients, publishing date and the authors' names have all been extracted from the articles and have been categorized in a table.Forty-six researches are included in this study. All three ways show that using chemotherapy after or with radiotherapy improves the vitality rate significantly (p-value< 0.01).It is concluded that after deciding not to perform a surgery for treating SCC, the recommended treatment plan is chemotherapy and radiotherapy simultaneously. https://fid.tums.ac.ir/index.php/fid/article/view/456 https://fid.tums.ac.ir/index.php/fid/article/download/456/432