Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 22 0 2025 09 16 4614 4614 Deepti Sharm Department of Oral and Maxillofacial Pathology, Christian Dental College & Hospital, Ludhiana, Punjab, India George Koshy Department of Oral and Maxillofacial Pathology, Christian Dental College & Hospital, Ludhiana, Punjab, India Merin S George Department of Oral and Maxillofacial Pathology, Christian Dental College & Hospital, Ludhiana, Punjab, India Vishal Sharma Department of Orthodontics, Desh Bhagat Dental College, Mandi Gobindgarh, Punjab, India 2022 09 29 2023 09 04 Organoids are among the most significant advancements in the past few years that have revolutionized the medical and dental research. These experimental organs have been used to study the developmental processes, pathophysiology, genetic mutations, and drug effects. The organoid technology is an important adjunct to two-dimensional culture methods and animal models. Stem cells are grown in specific environments to develop the organoids, thus, simulating the complexity of the in vivo environment. Oral organoids also recapitulate the architecture and functions of in vivo organs and tissues in the oral and maxillofacial region. Organoids are a promising tool to manipulate human dental stem cell biology for comprehending tooth-regenerative approaches, infectious diseases, genetic anomalies, oral cancer, and drug discovery. https://fid.tums.ac.ir/index.php/fid/article/view/4614 https://fid.tums.ac.ir/index.php/fid/article/download/4614/2163