Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 23 0 2026 04 27 4696 4696 Sogand Haghighatpasand . Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran Masoud Moradi Student Research Committee, School of Health, Mazandaran University of Medical Sciences, Sari, Iran Farshad Moradi Department of Orthodontics, School of Dentistry, Kurdistan University of Medical Sciences, Sanandaj, Iran Faranak Shafiee Department of Pediatric Dentistry, Faculty of Dentistry, Kurdistan University of Medical Sciences, Sanandaj, Iran 2022 12 13 2024 10 19 Objectives: Hypericum perforatum (H. perforatum) has natural anti-inflammatory properties when used as a dressing on ulcers and burn wounds. The aim of this study was to investigate the effect of topical application of hydroethanolic gel of H. perforatum on soft tissue healing in tooth extraction sockets. Materials and Methods: This split-mouth randomized controlled clinical trial was performed on 30 patients aged 18-30 years who required simultaneous extraction of maxillary premolars bilaterally for orthodontic reasons. After tooth extraction, 2mL of 3% H. perforatum gel was injected into the extraction socket in the intervention side. Pain was measured based on a Numeric Rating Scale (NRS). Socket healing was assessed using the standardized Landry, Turnbull, and Howley index. Repeated measures ANOVA and generalized estimating equations (GEE) were employed to compare different indices between the two groups (alpha=0.05). Results: The mean age of the participants was 23.53 years. Of all, 25 were females and 5 were males. The intervention side had a significantly lower pain than the control side (P<0.05). The wound size decreased at 3 and 7 days, and it was smaller in the intervention side than the control side (P<0.05). The healing index score was significantly higher in the intervention side than the control side (P<0.001). Conclusion: The results showed that 3% H. perforatum hydroethanolic gel was effective for promoting soft tissue healing in tooth extraction sockets, decreasing pain, and improving the wound healing index. https://fid.tums.ac.ir/index.php/fid/article/view/4696 https://fid.tums.ac.ir/index.php/fid/article/download/4696/2208