Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 21 0 2024 11 20 1 12 EN Mahsa Eshrati Research Center for Caries Prevention, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran Fatemeh Momeniha 2. Center for Solid Waste Research, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran 3. Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Nafiseh Momeni Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran Elham Ahmadi 4. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran 5. Department of Operative Dentistry, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Atieh Hashemian 4. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran 6. Department of Dental Biomaterials, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Homa Kashani Department of Research Methodology and Data Analysis, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran Mojgan Alaeddini Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran 2024 08 12 2024 10 18 Objectives: Dental clinics are one of the major producers of mercury-containing waste due to the use of dental amalgam.  The atmospheric transport and persistence of mercury and its compounds in the environment, coupled with their high potential for bioaccumulation and detrimental effects on human health and ecosystems, underscore the necessity for effective management of mercury waste. Due to the lack of comprehensive and integrated guidelines for the effective management of dental amalgam waste in Iran, the objective of this study was to adapt a guideline for the management of amalgam waste in dental settings within the country. Materials and Methods: The method used was based on the adaptation principles presented by the Ministry of Health and Medical Education, and included searching and reviewing guidelines related to the management of amalgam waste in developed countries, extracting recommendations, revising the recommendations considering the local infra-structures and conditions, and receiving expert opinions and reaching consensus according to the RAND/UCLA Appropriateness Method. Results: The final guideline includes 34 recommendations in 5 areas: manage-ment of the amalgam scraps, considerations for dental equipment, management of the extracted teeth containing amalgam restorations, management of the amalgam capsules, and considerations for placement and replacement of the amalgam restorations. Conclusion: The use of this guideline in medical universities, public and private dental clinics, along with the supervisory role of the Ministry of Health and Medical Education, can be a way to minimize the environmental hazards of mercury. https://fid.tums.ac.ir/index.php/fid/article/view/5317