Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 10 4 2013 07 15 351 7 Neda Moslemi Laser Research Center in Dentistry, Tehran University of Medical Sciences, Tehran, Iran ; Assistant Professor, Department of Periodontics, Tehran University of Medical Sciences, Tehran, Iran. Maryam Johari Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Sadegh Ahmad Akhoundi Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran ; Professor, Department of Orthodontic, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Hadi Zare Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran. Ahmad-Reza Shamshiri Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Azam Khorshidian Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 16 The aim of this randomized controlled clinical trial was to investigate the effect of a new Iranian toothpaste and a commercially available toothpaste containing desensitizing agent (5% potassium nitrate) on dentine hypersensitivity in a 24-week study.Fifty healthy volunteers, who had at least two sensitive root surfaces, completed the study period. The participants were randomly given one of the two toothpastes; Iranian (antihypersensitive Pooneh) or commercially available (fresh mint Sensodyne) toothpaste. Visual analogue scales (VASs) indicating the intensity of tooth hypersensitivity responding to tactile, airblast and cold-water stimuli were examined at baseline and weeks 2, 4, 12 and 24.Overall, VAS scores for tactile, airblast, and cold-water tests significantly reduced compared with the baseline in both groups (all P values https://fid.tums.ac.ir/index.php/fid/article/view/632 https://fid.tums.ac.ir/index.php/fid/article/download/632/607