Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 10 4 2013 07 15 296 302 Noushin Shokouhinejad Associate Professor, Dental Research Center, Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran ; Laser Research Center of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Naghmeh Meraji Postgraduate Student, Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Ahmad Reza Shamshiri Assistant Professor, Dental Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Mehrfam Khoshkhounejad Assistant Professor, Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Maryam Raoof Assistant Professor, Oral and Dental Diseases Research Center/Department of Endodontics, Kerman University of Medical Sciences, Kerman, Iran. 2015 10 16 To assess the effects of different final irrigants on the bond strength of bonded root filling materials, Epiphany/Resilon and Epiphany self-etch (SE)/Resilon.The root canals of eighty single-rooted extracted human teeth were prepared. After the smear layer was removed using 17% EDTA, the samples were randomly divided into eight groups. In groups 1 and 2, no additional irrigant was used after EDTA. In the other groups, final irrigation was performed with 2.5% NaOCl (groups 3 and 4), 2% chlorhexidine (CHX) (groups 5 and 6), and normal saline (groups 7 and 8). The root canals were obturated with Epiphany/Resilon in groups 1, 3, 5 and 7 and obturated with Epiphany SE/Resilon in groups 2, 4, 6 and 8. After the middle thirds of the roots were horizontally sectioned, the push-out bond strength of root filling materials was assessed using the universal testing machine. The data were analyzed using Mann-Whitney and Kruskal-Wallis tests. The significance level was set at p0.05). Considering the irrigation protocols, final irrigation with 2.5% NaOCl was associated with a significantly lower bond strength of both filling materials than the other irrigants (p0.05).Final irrigation of the root canals with 2.5% NaOCl following application of EDTA had a negative effect on the bond strength of Epiphany and Epiphany SE obturation systems. https://fid.tums.ac.ir/index.php/fid/article/view/645 https://fid.tums.ac.ir/index.php/fid/article/download/645/620