Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 3 1 2006 03 15 24 29 M. Basafa F. Farzanegan 2015 10 03 Statement of Problem: Bracket de-bonding during initial orthodontic archwire placement immediately after bracket set up or following re-bonding a single bracket can be a clinical concern. Purpose: The aim of this in vitro study was to assess the effect of time on the shear bond strength of a no-mix orthodontic composite adhesive. Materials and Methods: Seventy freshly extracted human upper first premolars were collected and stored in normal saline solution. The teeth were cleaned, polished, and randomly separated into 7 groups of 10. First premolar mesh-backed standard edgewise brackets were bonded to all specimens using a no-mix orthodontic composite adhesive. In the first 6 groups, the brackets were de-bonded 2, 5, 10, 15, 30 and 60 minutes after the primary setting time and the shear bond strengths were determined with the Universal testing machine. The teeth in group 7 were stored in 100% humidity at 37oC for 24 hours before de-bonding. Data were statistically analyzed with one-way ANOVA and the Duncan multiple range analyses via SPSS software. Results: The minimum shear bond strength of 14.03 MPa was observed in group 1. A statistically significant difference was found between the shear bond strength of group 1 and the other groups (P https://fid.tums.ac.ir/index.php/fid/article/view/77 https://fid.tums.ac.ir/index.php/fid/article/download/77/77