Tehran University of Medical Sciences Frontiers in Dentistry 2676-296X 13 4 2016 12 31 238 243 EN Alireza Heidari Assistant Professor, Department of Pediatric Dentistry, Dental School, Tehran University of Medical Sciences, Tehran, Iran Bahman Seraj Assistant Professor, Department of Pediatric Dentistry, Dental School, Tehran University of Medical Sciences, Tehran, Iran Mahdi Shahrabi Associate Professor, Department of Pediatric Dentistry, School of Dentistry, Tehran University of Medical Sciences. Tehran, Iran. Hamideh Maghsoodi Private Practice, Tehran, Iran Dentist Mohammad Javad Kharazi Fard Statistical Consultant and Research adviser , Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran Tara Zarabian Pedodontist, Department of Pediatric Dentistry, School of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran 2015 12 04 2016 03 29 Objectives: Asthma is a common chronic disease. Asthma and anti-asthmatic medications have been suggested as risk factors for increased susceptibility to caries. This study was conducted to evaluate the effects of different types and forms of antihistaminic medications and the duration of drug consumption on the severity of dental caries in asthmatic children. Materials and Methods: This cross-sectional study was conducted in Asthma and Allergy Department of Children’s Medical Center in Tehran, Iran. Eighty-five children between three to 12 years who had been diagnosed with asthma, by means of taking medical history, clinical examination and spirometry were chosen by non-simple random sampling. The participants and their parents were interviewed. Oral examination was performed by a qualified dentist. The data were collected by use of questionnaires and analyzed by the stepwise multivariate linear regression analysis, using SPSS version 16. P<0.05 was considered statistically significant. Results: There was a significant correlation between the number of cetirizine and ketotifen tablets taken and decayed/missing/filled (dmf/DMF) teeth score (P=0.006). There were no correlations between the number of consumed sprays and dmf/DMF score (P=0.923), the duration of drug therapy (P=0.907) or the type of medication taken including ß2 agonists, antihistamines, steroids or a combination of them (P=0.907). Conclusions: The present study showed that the tablet form of medications significantly increased the severity of dental caries even in presence of confounders (sex, age, duration of disease, tooth brushing, sugar consumption, fluoride therapy, mouth dryness).   https://fid.tums.ac.ir/index.php/fid/article/view/934 https://fid.tums.ac.ir/index.php/fid/article/download/934/892