Radiographic Comparison of Bovine Bone Substitute Alone versus Bovine Bone Substitute and Simvastatin for Human Maxillary Sinus Augmentation

Amir Ali Reza Rasouli Ghahroudi; Afshin Khorsand; Sanaz Mahmoodi; Sahar Chokami Rafiei

Radiographic Comparison of Bovine Bone Substitute Alone versus Bovine Bone Substitute and Simvastatin for Human Maxillary Sinus Augmentation

Amir Ali Reza Rasouli Ghahroudi

Afshin Khorsand

Sanaz Mahmoodi

Sahar Chokami Rafiei

Abstract

Objectives: The aim of this study was to compare the efficacy of bovine bone substitute (Compact Bone B. ®) alone versus bovine bone substitute and simvastatin for human maxillary sinus augmentation.
Materials and Methods: This study was conducted on 16 sinuses in eight patients. Radiographic assessments were done preoperatively (T0), immediately (T1) and at nine months after sinus grafting (T2). Alveolar bone height and density were assessed on cone beam computed tomography (CBCT) scans using Planmeca Romexis™ Imaging Software 2.2.
Results: The change in alveolar bone height and density between T0, T1 and T2 was significant in both groups. Alveolar bone height (h0, h1, h2) and vertical height of the grafted bone (g1, g2) in three lines (anterior, middle and posterior) were not significantly different between groups. The grafted bone height shrinkage (%) in the anterior, middle and posterior limits of the augmented area were not significantly different between groups. The existing alveolar and grafted bone density increased significantly in both groups between T1 and T2, except for the existing alveolar bone density in the control group. There were no statistically significant differences between the alveolar bone density values obtained in TI and T2 between groups, except for the existing alveolar bone density at T1.
Conclusions: This study did not show any significant positive effect for simvastatin in maxillary sinus augmentation based on radiographic examination.

- Panagiotou D, Karaca EÖ, İpçi ŞD, Çakar G, Olgaç V, Yılmaz S. Comparison of two different xenografts in bilateral sinus augmentation: radiographic and histologic findings. Quintessence Int. 2015 Jul-Aug;46(7):611-9.

- Wagner F, Dvorak G, Nemec S, Pietschmann P, Figl M, Seemann R. A principal components analysis: how pneumatization and edentulism contribute to maxillary atrophy. Oral Dis. 2017 Jan;23(1):55-61.

- Velasco-Torres M, Padial-Molina M, Avila-Ortiz G, García-Delgado R, O'Valle F, Catena A, et al. Maxillary sinus dimensions decrease as age and tooth loss increase. Implant Dent. 2017 Apr;26(2):288-95.

- Froum SJ, Wallace S, Cho SC, Khouly I, Rosenberg E, Corby P, et al. Radiographic comparison of different concentrations of recombinant human bone morphogenetic protein with allogenic bone compared with the use of 100% mineralized cancellous bone allograft in maxillary sinus grafting. Int J Periodontics Restorative Dent. 2014 Sep-Oct;34(5):611-20.

- Kan JY, Roe P, Rungcharassaeng K. Effects of implant morphology on rotational stability during immediate implant placement in the esthetic zone. Int J Oral Maxillofac Implants. 2015 May;30(3).

- Lundgren S, Cricchio G, Hallman M, Jungner M, Rasmusson L, Sennerby L. Sinus floor elevation procedures to enable implant placement and integration: techniques, biological aspects and clinical outcomes. Periodontol 2000. 2017 Feb;73(1):103-20.

- Starch-Jensen T, Aludden H, Hallman M, Dahlin C, Christensen AE, Mordenfeld A. A systematic review and meta-analysis of long-term studies (five or more years) assessing maxillary sinus floor augmentation. Int J Oral Maxillofac Surg. 2017 May 22. pii: S0901-5027(17)31449-2.

- Pohl V, Thoma DS, Sporniak‐Tutak K, Garcia‐Garcia A, Taylor TD, Haas R, et al. Short dental implants (6 mm) versus long dental implants (11‐15 mm) in combination with sinus floor elevation procedures: 3‐year results from a multi‐center, randomized, controlled clinical trial. J Clin Periodontol. 2017 Apr;44(4):438-45.

- Schulman L, Jensen O. Academy of osseointegration: Sinus graft consensus conference. Int J Oral Maxillofac Implants. 1998;13:11-45.

- Urban IA, Lozada JL. A prospective study of implants placed in augmented sinuses with minimal and moderate residual crestal bone: results after 1 to 5 years. Int J Oral Maxillofac Implants. 2010 Nov-Dec;25(6):1203-12.

- Hatano N, Shimizu Y, Ooya K. A clinical long‐term radiographic evaluation of graft height changes after maxillary sinus floor augmentation with a 2: 1 autogenous bone/xenograft mixture and simultaneous placement of dental implants. Clin Oral Implants Res. 2004 Jun;15(3): 339-45.

- Ahmet S, Gultekin BA, Karabuda ZC, Olgac V. Two composite bone graft substitutes for maxillary sinus floor augmentation: Histological, histomorphometric, and radiographic analyses. Implant Dent. 2016 Jun;25(3):313-21.

- Gultekin BA, Cansiz E, Borahan O, Mangano C, Kolerman R, Mijiritsky E, et al. Evaluation of volumetric changes of augmented maxillary sinus with different bone grafting biomaterials. J Craniofac Surg. 2016 Mar;27(2): e144-e8.

- Grolli Klein GB, Curvello VP, Dutra RA, Simeão SP, dos Santos PL, Gulinelli JL. Bone Volume Changes After Sinus Floor Augmentation with Heterogenous Graft. Int J Oral Maxillofac Implants. 2016 May-Jun;31(3):665-71.

- Kahnberg KE, Nilsson P, Hirsch JM, Ekestubbe A, Gröndahl K. Sinus lifting procedure. Clin Oral Implants Res. 2001 Oct;12(5):479-87.

- Bergh J, Bruggenkate CM, Disch FJ, Tuinzing DB. Anatomical aspects of sinus floor elevations. Clin Oral Implants Res. 2000 Jun;11(3):256-65.

- Gray CF, Redpath TW, Bainton R, Smith FW. Magnetic resonance imaging assessment of a sinus lift operation using reoxidised cellulose (SurgicelR) as graft material. Clin Oral Implants Res. 2001 Oct;12(5):526-30.

- Wiltfang J, Schultze-Mosgau S, Merten HA, Kessler P, Ludwig A, Engelke W. Endoscopic and ultrasonographic evaluation of the maxillary sinus after combined sinus floor augmentation and implant insertion. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Mar;89(3):288-91.

- Molteni R. Prospects and challenges of rendering tissue density in Hounsfield units for cone beam computed tomography. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jul;116(1):105-19.

- Feragalli B, Rampado O, Abate C, Macrì M, Festa F, Stromei F, et al. Cone beam computed tomography for dental and maxillofacial imaging: technique improvement and low-dose protocols. Radiol Med. 2017 Apr:1-8.

- Suomalainen A, Vehmas T, Kortesniemi M, Robinson S, Peltola J. Accuracy of linear measurements using dental cone beam and conventional multislice computed tomography. Dentomaxillofac Radiol. 2008 Jan;37(1):10-7.

- Montazerolghaem M, Rasmusson A, Melhus H, Engqvist H, Ott MK. Simvastatin-doped pre-mixed calcium phosphate cement inhibits osteoclast differentiation and resorption. J Mater Sci Mater Med. 2016 May;27(5):83.

- Tan J, Yang N, Fu X, Cui Y, Guo Q, Ma T, et al. Single-dose local simvastatin injection improves implant fixation via increased angiogenesis and bone formation in an ovariectomized rat model. Med. Sci. Monit. 2015; 21: 1428.

- Killeen AC, Rakes PA, Schmid MJ, Zhang Y, Narayana N, Marx DB, et al. Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects. J Periodontol. 2012 Dec;83(12):1463-71.

- Rutledge J, Schieber MD, Chamberlain JM, Byarlay M, Killeen AC, Giannini PJ, et al. Simvastatin application to augment facial jaw bone in a dog model: pilot study. J Periodontol. 2011 Apr;82(4):597-605.

- Nyan M, Sato D, Kihara H, Machida T, Ohya K, Kasugai S. Effects of the combination with alpha-tricalcium phosphate and simvastatin on bone regeneration. Clin Oral Implants Res. 2009 Mar;20(3):280-7.

- Maciel-Oliveira N, Bradaschia-Correa V, Arana-Chavez VE. Early alveolar bone regeneration in rats after topical administration of simvastatin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Aug;112(2):170-9.

- Morris MS, Lee Y, Lavin MT, Giannini PJ, Schmid MJ, Marx DB, et al. Injectable simvastatin in periodontal defects and alveolar ridges: pilot studies. J Periodontol. 2008 Aug;79(8):1465-73.

- Marchand-Libouban H, Guillaume B, Bellaiche N, Chappard D. Texture analysis of computed tomographic images in osteoporotic patients with sinus lift bone graft reconstructionClin Oral Investig. 2013;17(4):1267-72.

- Kinra P, Khan S. Simvastatin: Its potential new role in periodontal regeneration. Biol and Med. 2011;3(2):215-21.

- Ozyuvaci H, Bilgic B, Firatli E. Radiologic and histomorphometric evaluation of maxillary sinus grafting with alloplastic graft materials. J Periodontol. 2003 Jun;74(6):909-15.

- Valentini P, Abensur D, Densari D, Graziani J, Hämmerle C. Histological evaluation of Bio-Oss in a 2-stage sinus floor elevation and implantation procedure. A human case report. Clin Oral Implants Res. 1998 Feb;9(1):59-64.

- Chanavaz M. Maxillary sinus: anatomy, physiology, surgery, and bone grafting related to implantology--eleven years of surgical experience (1979-1990). J Oral Implantol. 1989 Dec;16(3):199-209.

- Hürzeler MB, Kirsch A, Ackermann KL, Quiñones CR. Reconstruction of the severely resorbed maxilla with dental implants in the augmented maxillary sinus: a 5-year clinical investigation. Int J Oral Maxillofac Implants. 1996 Jul-Aug;11(4):466-75.

- Pedersen KN, Haanæs HR, Fæhn O. Subperiosteal transmucosal porous ceramic/ titanium implants: Clinical experience from three cases. Int J Oral Surg. 1979 Oct;8(5):349-55.

- Brånemark P, Adell R, Albrektsson T, Lekholm U, Lindström J, Rockler B. An experimental and clinical study of osseointegrated implants penetrating the nasal cavity and maxillary sinus. J Oral Maxillofac Surg. 1984 Aug;42(8):497-505.

- Hallman M, Hedin M, Sennerby L, Lundgren S. A prospective 1-year clinical and radiographic study of implants placed after maxillary sinus floor augmentation with bovine hydroxyapatite and autogenous bone. J Oral Maxillofac Surg. 2002 Mar;60(3):277-84.

- Kircos LT, Misch CE. Diagnostic imaging and techniques. Contemporary Implant Dentistry. Edited by: Misch CE. 1999, St Louis, Missouri, Mosby-Year Book: 73-87.

- Norton MR, Gamble C. Bone classification: an objective scale of bone density using the computerized tomography scan. Clin Oral Implants Res. 2001 Feb;12(1):79-84.

- Fuh LJ, Huang HL, Chen CS, Fu KL, Shen YW, Tu MG, et al. Variations in bone density at dental implant sites in different regions of the jawbone. J Oral Rehabil. 2010 May;37(5):346-51.

- Uzbek UH, Rahman SA, Alam MK, Gillani SW. Bone forming potential of an-organic bovine bone graft: A cone beam CT study. J Clin Diagn Res. 2014 Dec;8(12):ZC73.

- Lima CE, Calixto JC, Anbinder AL. Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats. Braz Oral Res. 2011 Feb;25(1):42-8.

- Chauhan AS, Maria A, Managutti A. Efficacy of simvastatin in bone regeneration after surgical removal of mandibular third molars: A clinical pilot study. J Maxillofac Oral Surg. 2015 Sep;14(3):578-85.

- Wallace SS, Froum SJ, Cho SC, Elian N, Monteiro D, Kim BS, et al. Sinus augmentation utilizing anorganic bovine bone (Bio-Oss) with absorbable and nonabsorbable membranes placed over the lateral window: histomorphometric and clinical analyses. Int J Periodontics Restorative Dent. 2005 Dec;25(6).

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Issue	Vol 15, No 1 (2018)
Section	Original Article
Keywords
Cone-Beam Computed Tomography Sinus Floor Augmentation Simvastatin

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Rasouli Ghahroudi AAR, Khorsand A, Mahmoodi S, Chokami Rafiei S. Radiographic Comparison of Bovine Bone Substitute Alone versus Bovine Bone Substitute and Simvastatin for Human Maxillary Sinus Augmentation. Front Dent. 2018;15(1):20-29.

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