Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature
-
Monir Moradzadeh
,
Abbas Karimi
,
Hassan Mirmohammad Sadeghi
,
Samira Derakhshan
,
Seyed Mobin Tafreshi
,
Samar Jalali
Abstract
Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed.
1. Hosur MB, Puranik RS, Vanaki SS, Puranik SR, Ingaleshwar PS. Clinicopathological profile of central giant cell granulomas: An institutional experience and study of immunohistochemistry expression of p63 in central giant cell granuloma. J Oral Maxillofacial Pathol. 2018 May;22(2):173-9.
2. Jadu F, Pharoah M, Lee L, Baker G, Allidina A. Central giant cell granuloma of the mandibular condyle: a case report and review of the literature. Dentomaxillofac Rad 2011 Jan;40(1):60-4.
3. Kruse-Losler B, Diallo R, Gaertner C, Mischke KL, Joos U, Kleinheinz J. Central giant cell granuloma of the jaws: a clinical, radiologic, and histopathologic study of 26 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):346-54.
4. de Lange J, van den Akker HP, van den Berg H. Central giant cell granuloma of the jaw: a review of the literature with emphasis on therapy options. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Nov;104(5):603-15.
5. Abdelkarim AZ, el Sadat SMA, Chmieliauskaite M, Syed AZ. Radiographic diagnosis of a central giant cell granuloma using advanced imaging: cone beam computed tomography. Cureus 2018 Jun;10(6): e2735.
6. de Lange J, van Maarle MC, van den Akker HP, Redeker EJ. DNA analysis of the SH3BP2 gene in patients with aggressive central giant cell granuloma. Br J Oral Maxillofac Surg. 2007 Sep;45(6):499-500.
7. Upadhyaya JD, Cohen DM, Islam MN, Bhattacharyya I. Hybrid central odontogenic fibroma with giant cell granuloma like lesion: a report of three additional cases and review of the literature. Head and Neck Pathol. 2018;12(2):166-74.
8. Neville BW, Damm DD, Allen CM, Chi AC. Oral and maxillofacial pathology. 4th ed. St. Louis: Elsevier; 2016:676.
9. Wangerin K, Harms D. Seltene Variationen des ameloblastischen Fibroms. Dtsch Z Mund Kiefer Gesichtschir. May-Jun 1985;9(3):227-31.
10. Fowler C, Tomich C, Brannon R, Houston G. Central odontogenic fibroma: clinicopathologic features of 24 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1993;76:587.
11. Kruse-Lösler B, Diallo R, Gaertner C, Mischke KL, Joos U, Kleinheinz J. Central giant cell granuloma of the jaws: a clinical, radiologic, and histopathologic study of 26 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):346-54.
12. Hassan S, Reich R, Freedman P, editors. Central odontogenic fibroma with associated central giant cell granuloma (Collision tumor?): report of 7 cases. 62nd Annual Meeting, American Academy of Oral and Maxillofacial Pathology San Francisca; 2008.
13. Leite T, Mendes E, Abrahao A, Andrade B, Canedo N, Agostini M, et al. Central odontogenic fibroma: report of three new cases from Brazil. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2017 Sep;124(3):e229-30.
14. Schultz K, Rosebush M, editors. Clinical pathologic conference case 3. Annual Meeting of the American Academy of Oral and Maxillofacial Pathology Newport, Rhode Island; 2017.
15. Allen CM, Hammond HL, Stimson PG. Central odontogenic fibroma, WHO∗ type: a report of three cases with an unusual associated giant cell reaction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1992 Jan;73(1):62-6.
16. Odell E, Lombardi T, Barrett A, Morgan P, Speight P. Hybrid central giant cell granuloma and central odontogenic fibroma‐like lesions of the jaws. Histopathology 1997 Feb;30(2):165-71.
17. Marina de Deus Moura de L, de Aquino Xavier FC, Vanti LA, de Lima PS, de Sousa SC. Hybrid central giant cell granuloma and central odontogenic fibroma-like lesion of the mandible. Otolaryngol Head Neck 2008 Dec;139(6):867-8.
18. Damm D. Interradicular radiolucency. Hybrid giant cell granuloma and odontogenic fibroma. Gen Dent. 2013 May-Jun;61(3):77-8.
19. Taylor AM, Flores VB, Franco MAD. Combined central odontogenic fibroma and giant cell granuloma-like lesion of the mandible: report of a case and review of the literature. J Oral and Maxillofac Surg. 1999 Oct;57(10):1258-62.
20. Castillo GC, Reyes RL, Mosqueda Taylor A. Lesión mandibular inusual de fibroma odontogénico central combinado con granuloma central de células gigantes mandibular. Revista Odontológica Mexicana. 2011;15(2):126-31.
21. Mosqueda-Taylor A, Martínez-Mata G, Carlos-Bregni R, Vargas PA, Toral-Rizo V, Cano-Valdéz AM, et al. Central odontogenic fibroma: new findings and report of a multicentric collaborative study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Sep;112(3):349-58.
22. Flores-Hidalgo A, Biggerstaff T, Murrah V. Hybrid central odontogenic fibroma and central giant cell granuloma lesion–A case report of an aggressive and recurrent lesion. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2019 Nov;31(6):432-4.
23. Tosios KI, Gopalakrishnan R, Koutlas IG. So-called hybrid central odontogenic fibroma/central giant cell lesion of the jaws. A report on seven additional cases, including an example in a patient with cherubism, and hypotheses on the pathogenesis. Head Neck Pathol 2008 Dec;2(4):333-8.
24. Eversole LR. Odontogenic fibroma, including amyloid and ossifying variants. Head Neck Pathol 2011 Dec;5(4):335-43.
25. Younis RH, Scheper MA, Lindquist C, Levy B. Hybrid central odontogenic fibroma with giant cell granuloma-like component: case report and review of literature. Head Neck Pathol 2008 Sep;2(3):222-6.
26. Vijintanawan S, Chettri K, Aittiwarapoj A, Wongsirichat N. Hybrid central odontogenic fibroma with central giant cell granuloma like lesion; A case report and review of the literature. Siriraj Med J 2019 Sep;71(5):426-31.
27. Bologna-Molina R, Pacheco Ruiz L, Mosqueda Taylor A, Huesca Ramirez HG, Ponce Lonato JA, González González R. Central odontogenic fibroma combined with central giant cell lesion of the mandible. Immunohistochemical profile. J Clin Exp Dent 2011; 3(4):e348-51.
28. Eliot C, Kessler HP. Clinical pathologic conference case 1: a multilocular radiolucency in the posterior mandible. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Jun;119(6):e289-92.
29. Ramadan OR, Essawy MM. Central odontogenic fibroma with giant cell granuloma-like lesion: A report of an additional case and review of literature. Head Neck Pathol. 2021 Mar;15(1):275.
2. Jadu F, Pharoah M, Lee L, Baker G, Allidina A. Central giant cell granuloma of the mandibular condyle: a case report and review of the literature. Dentomaxillofac Rad 2011 Jan;40(1):60-4.
3. Kruse-Losler B, Diallo R, Gaertner C, Mischke KL, Joos U, Kleinheinz J. Central giant cell granuloma of the jaws: a clinical, radiologic, and histopathologic study of 26 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):346-54.
4. de Lange J, van den Akker HP, van den Berg H. Central giant cell granuloma of the jaw: a review of the literature with emphasis on therapy options. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Nov;104(5):603-15.
5. Abdelkarim AZ, el Sadat SMA, Chmieliauskaite M, Syed AZ. Radiographic diagnosis of a central giant cell granuloma using advanced imaging: cone beam computed tomography. Cureus 2018 Jun;10(6): e2735.
6. de Lange J, van Maarle MC, van den Akker HP, Redeker EJ. DNA analysis of the SH3BP2 gene in patients with aggressive central giant cell granuloma. Br J Oral Maxillofac Surg. 2007 Sep;45(6):499-500.
7. Upadhyaya JD, Cohen DM, Islam MN, Bhattacharyya I. Hybrid central odontogenic fibroma with giant cell granuloma like lesion: a report of three additional cases and review of the literature. Head and Neck Pathol. 2018;12(2):166-74.
8. Neville BW, Damm DD, Allen CM, Chi AC. Oral and maxillofacial pathology. 4th ed. St. Louis: Elsevier; 2016:676.
9. Wangerin K, Harms D. Seltene Variationen des ameloblastischen Fibroms. Dtsch Z Mund Kiefer Gesichtschir. May-Jun 1985;9(3):227-31.
10. Fowler C, Tomich C, Brannon R, Houston G. Central odontogenic fibroma: clinicopathologic features of 24 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1993;76:587.
11. Kruse-Lösler B, Diallo R, Gaertner C, Mischke KL, Joos U, Kleinheinz J. Central giant cell granuloma of the jaws: a clinical, radiologic, and histopathologic study of 26 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):346-54.
12. Hassan S, Reich R, Freedman P, editors. Central odontogenic fibroma with associated central giant cell granuloma (Collision tumor?): report of 7 cases. 62nd Annual Meeting, American Academy of Oral and Maxillofacial Pathology San Francisca; 2008.
13. Leite T, Mendes E, Abrahao A, Andrade B, Canedo N, Agostini M, et al. Central odontogenic fibroma: report of three new cases from Brazil. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2017 Sep;124(3):e229-30.
14. Schultz K, Rosebush M, editors. Clinical pathologic conference case 3. Annual Meeting of the American Academy of Oral and Maxillofacial Pathology Newport, Rhode Island; 2017.
15. Allen CM, Hammond HL, Stimson PG. Central odontogenic fibroma, WHO∗ type: a report of three cases with an unusual associated giant cell reaction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1992 Jan;73(1):62-6.
16. Odell E, Lombardi T, Barrett A, Morgan P, Speight P. Hybrid central giant cell granuloma and central odontogenic fibroma‐like lesions of the jaws. Histopathology 1997 Feb;30(2):165-71.
17. Marina de Deus Moura de L, de Aquino Xavier FC, Vanti LA, de Lima PS, de Sousa SC. Hybrid central giant cell granuloma and central odontogenic fibroma-like lesion of the mandible. Otolaryngol Head Neck 2008 Dec;139(6):867-8.
18. Damm D. Interradicular radiolucency. Hybrid giant cell granuloma and odontogenic fibroma. Gen Dent. 2013 May-Jun;61(3):77-8.
19. Taylor AM, Flores VB, Franco MAD. Combined central odontogenic fibroma and giant cell granuloma-like lesion of the mandible: report of a case and review of the literature. J Oral and Maxillofac Surg. 1999 Oct;57(10):1258-62.
20. Castillo GC, Reyes RL, Mosqueda Taylor A. Lesión mandibular inusual de fibroma odontogénico central combinado con granuloma central de células gigantes mandibular. Revista Odontológica Mexicana. 2011;15(2):126-31.
21. Mosqueda-Taylor A, Martínez-Mata G, Carlos-Bregni R, Vargas PA, Toral-Rizo V, Cano-Valdéz AM, et al. Central odontogenic fibroma: new findings and report of a multicentric collaborative study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Sep;112(3):349-58.
22. Flores-Hidalgo A, Biggerstaff T, Murrah V. Hybrid central odontogenic fibroma and central giant cell granuloma lesion–A case report of an aggressive and recurrent lesion. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2019 Nov;31(6):432-4.
23. Tosios KI, Gopalakrishnan R, Koutlas IG. So-called hybrid central odontogenic fibroma/central giant cell lesion of the jaws. A report on seven additional cases, including an example in a patient with cherubism, and hypotheses on the pathogenesis. Head Neck Pathol 2008 Dec;2(4):333-8.
24. Eversole LR. Odontogenic fibroma, including amyloid and ossifying variants. Head Neck Pathol 2011 Dec;5(4):335-43.
25. Younis RH, Scheper MA, Lindquist C, Levy B. Hybrid central odontogenic fibroma with giant cell granuloma-like component: case report and review of literature. Head Neck Pathol 2008 Sep;2(3):222-6.
26. Vijintanawan S, Chettri K, Aittiwarapoj A, Wongsirichat N. Hybrid central odontogenic fibroma with central giant cell granuloma like lesion; A case report and review of the literature. Siriraj Med J 2019 Sep;71(5):426-31.
27. Bologna-Molina R, Pacheco Ruiz L, Mosqueda Taylor A, Huesca Ramirez HG, Ponce Lonato JA, González González R. Central odontogenic fibroma combined with central giant cell lesion of the mandible. Immunohistochemical profile. J Clin Exp Dent 2011; 3(4):e348-51.
28. Eliot C, Kessler HP. Clinical pathologic conference case 1: a multilocular radiolucency in the posterior mandible. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Jun;119(6):e289-92.
29. Ramadan OR, Essawy MM. Central odontogenic fibroma with giant cell granuloma-like lesion: A report of an additional case and review of literature. Head Neck Pathol. 2021 Mar;15(1):275.
| Issue | Vol 18 (Continuously Published Article-Based) | |
| Section | Case Report | |
| DOI | https://doi.org/10.18502/fid.v18i44.8340 | |
| Keywords | ||
| Granuloma Giant Cell; Fibroma; Odontogenic Tumors | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Moradzadeh M, Karimi A, Mirmohammad Sadeghi H, Derakhshan S, Tafreshi SM, Jalali S. Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature. Front Dent. 2022;18.
