A Primary Intraosseous Rhabdomyosarcoma of Mandible: Report of a Rare Case and Review of Literature
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Abstract
Rhabdomyosarcoma is a rare soft tissue malignant neoplasm with striated muscle differentiation often found in the head and neck region. In our case a 33-year-old man presented with a bulging mass near his right mandibular second molar tooth, identified as a unilocular destructive lesion on an X-ray. An incisional biopsy confirmed rhabdomyosarcoma, leading to a hemi-mandibulectomy. Histopathologic findings showed spindle and rhabdoid cells with positive immunoreactivity to Desmin, myogenin and myoD1. In conclusion, it is crucial to differentiate rhabdomyosarcoma from other more common intraosseous malignancies, and using Desmin staining as part of the initial immunohistochemical panel can aid in the diagnosis process.
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11. Joy T, Tupkari JV, Hanchate AV, Siwach P. Oral rhabdomyosarcoma in an adult male: A rare case report. J Oral Maxillofac Pathol. 2018 May-Aug;22(2):285.
12. Sadhasivam V, Sherwood IA, Gutmann JL, Gururaj N, Mahalakshmi V, Doss DM. Spindle cell rhabdomyosarcoma of the anterior mandible manifesting as a periapical lesion of pulpal origin: Case report. Aust Endod J. 2019 Apr;45(1):129-134.
2. Shrutha SP, Vinit GB. Rhabdomyosarcoma in a pediatric patient: A rare case report. Contemp Clin Dent. 2015 Jan-Mar;6(1):113-5.
3. Hartmann S, Lessner G, Mentzel T, Kübler AC, Müller-Richter UD. An adult spindle cell rhabdomyosarcoma in the head and neck region with long-term survival: a case report. J Med Case Rep. 2014 Jun 19;8:208.
4. Arul AS, Verma S, Arul AS, Verma R. Oral rhabdomyosarcoma-embryonal subtype in an adult: A rarity. J Nat Sci Biol Med. 2014 Jan;5(1):222-5.
5. Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, et al. Rhabdomyosarcoma: current challenges and their implications for developing therapies. Cold Spring Harb Perspect Med. 2014 Nov 3;4(11):a025650.
6. Loducca SV, Mantesso A, de Oliveira EM, de Araújo VC. Intraosseous rhabdomyosarcoma of the mandible: a case report. Int J Surg Pathol. 2003 Jan;11(1):57-60.
7. Rudzinski ER, Anderson JR, Hawkins DS, Skapek SX, Parham DM, Teot LA. The World Health Organization Classification of Skeletal Muscle Tumors in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group. Arch Pathol Lab Med. 2015 Oct;139(10):1281-7.
8. Sudhakar S, Geethika V, Rao N, Smitha B, Kiran ChS. Alveolar rhabdomyosarcoma on the left maxillary alveolus: a unique presentation. J Clin Diagn Res. 2015 Feb;9(2):ZD07-9.
9. Kimario OM, Washngton L, Aloyce A, Mbunda F, Donasiano A, Saitabau Z, et al. Rhabdomyosarcoma in a Female Adult a Rare Case Report at BMC Mwanza. East African Scholars J Med Surg. 2021 Aug;3(8):136-8.
10. Rodrigues-Fernandes CI, Sánchez-Romero C, de Almeida OP, Alves FA, Carvalho EJA, de Castro JFL, et al. Oral epithelioid rhabdomyosarcoma: Report of a rare case and literature review of a distinct variant of rhabdomyosarcoma. Oral Oncol. 2022 Jan;124:105498.
11. Joy T, Tupkari JV, Hanchate AV, Siwach P. Oral rhabdomyosarcoma in an adult male: A rare case report. J Oral Maxillofac Pathol. 2018 May-Aug;22(2):285.
12. Sadhasivam V, Sherwood IA, Gutmann JL, Gururaj N, Mahalakshmi V, Doss DM. Spindle cell rhabdomyosarcoma of the anterior mandible manifesting as a periapical lesion of pulpal origin: Case report. Aust Endod J. 2019 Apr;45(1):129-134.
| Issue | Vol 22 (Continuously Published Article-Based) | |
| Section | Case Report | |
| DOI | https://doi.org/10.18502/fid.v22i4.17543 | |
| Keywords | ||
| Rhabdomyosarcoma Mandible; Neoplasm | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Mashhadi S, Garajei A, Aminishakibb P. A Primary Intraosseous Rhabdomyosarcoma of Mandible: Report of a Rare Case and Review of Literature. Front Dent. 2025;22.
