Solitary Fibrous Tumor of the Lower Lip; A Rare Case Report
A rare case report
Abstract
Solitary Fibrous Tumor (SFT) is a rare benign neoplasm primarily associated with the pleura. However, it has also been identified in diverse locations, including the skin, deep soft tissues, genitourinary system, gastrointestinal tract, and the head and neck region, including the oral cavity. There is no gender predilection for SFT of the oral cavity and it can occur at any age. We herein present a case of SFT on the lower lip of a 19-year-old male patient and describe our diagnostic approach. The histopathological findings showed typical features of SFT with immunoexpression of CD34, CD99, BCL2, and STAT6, along with low expression of Ki67 in 10% of the tumor cells.
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3. O'Regan EM, Vanguri V, Allen CM, Eversole LR, Wright JM, Woo SB. Solitary fibrous tumor of the oral cavity: clinicopathologic and immunohistochemical study of 21 cases. Head Neck Pathol. 2009 Jun;3(2):106-15.
4. Ronchi A, Cozzolino I, Zito Marino F, Accardo M, Montella M, Panarese I, et al. Extrapleural solitary fibrous tumor: A distinct entity from pleural solitary fibrous tumor. An update on clinical, molecular and diagnostic features. Ann Diagn Pathol. 2018 Jun;34:142-150.
5. Nunes FB, Sant'Ana MSP, Silva AMB, Agostini M, Silva Canedo NH, de Andrade BAB, et al. Solitary fibrous tumour of the oral cavity: An update. J Oral Pathol Med. 2020 Jan;49(1):14-20.
6. Geramizadeh B, Marzban M, Churg A. Role of Immunohistochemistry in the Diagnosis of Solitary Fibrous Tumor, a Review. Iran J Pathol. 2016 Summer;11(3):195-203.
7. Davanzo B, Emerson RE, Lisy M, Koniaris LG, Kays JK. Solitary fibrous tumor. Transl Gastroenterol Hepatol. 2018 Nov 21;3:94.
8. Rodríguez-Gil Y, González MA, Carcavilla CB, Santamaría JS. Lines of cell differentiation in solitary fibrous tumor: an ultrastructural and immunohistochemical study of 10 cases. Ultrastruct Pathol. 2009 Dec;33(6):274-85.
9. Cummings TJ, Burchette JL, McLendon RE. CD34 and dural fibroblasts: the relationship to solitary fibrous tumor and meningioma. Acta Neuropathol. 2001 Oct;102(4):349-54.
10. Gold JS, Antonescu CR, Hajdu C, Ferrone CR, Hussain M, Lewis JJ, Brennan MF, Coit DG. Clinicopathologic correlates of solitary fibrous tumors. Cancer. 2002 Feb 15;94(4):1057-68.
11. Dungarwalla MM, Barrett AW, Gulati A. Solitary fibrous tumour of the tongue: a series of four cases. J Laryngol Otol. 2017 Sep;131(9):838-841.
12. Doyle LA, Vivero M, Fletcher CD, Mertens F, Hornick JL. Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Mod Pathol. 2014 Mar;27(3):390-5.
13. Schmitz J, Radbruch A. Immunoglobulin class switching. In: Delves PJ, editor. Encyclopedia of Immunology. 2nd ed. Oxford, UK: Elsevier; 1998. p. 1302-1306.
14. Robinson DR, Wu YM, Kalyana-Sundaram S, Cao X, Lonigro RJ, Sung YS, et al. Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet. 2013 Feb;45(2):180-5.
15. Barthelmeß S, Geddert H, Boltze C, Moskalev EA, Bieg M, Sirbu H, et al. Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features. Am J Pathol. 2014 Apr;184(4):1209-1218.
16. Gengler C, Guillou L. Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology. 2006 Jan;48(1):63-74.
17. Bauer JL, Miklos AZ, Thompson LD. Parotid gland solitary fibrous tumor: a case report and clinicopathologic review of 22 cases from the literature. Head Neck Pathol. 2012 Mar;6(1):21-31.
18. Lo Muzio L, Mascolo M, Capodiferro S, Favia G, Maiorano E. Solitary fibrous tumor of the oral cavity: the need for an extensive sampling for a correct diagnosis. J Oral Pathol Med. 2007 Oct;36(9):538-42.
19. Diebold M, Soltermann A, Hottinger S, Haile SR, Bubendorf L, Komminoth P, et al. Prognostic value of MIB-1 proliferation index in solitary fibrous tumors of the pleura implemented in a new score - a multicenter study. Respir Res. 2017 Dec 16;18(1):210.
20. Ridder GJ, Kayser G, Teszler CB, Pfeiffer J. Solitary fibrous tumors in the head and neck: new insights and implications for diagnosis and treatment. Ann Otol Rhinol Laryngol. 2007 Apr;116(4):265-70.
21. Cox DP, Daniels T, Jordan RC. Solitary fibrous tumor of the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jul;110(1):79-84.
2. Neville BW, Damm DD, Allen CM, Chi AC. Solitary fibrous tumor. In: Oral and maxillofacial pathology. 4th ed. Elsevier Health Sciences; 2015. p. 480-481.
3. O'Regan EM, Vanguri V, Allen CM, Eversole LR, Wright JM, Woo SB. Solitary fibrous tumor of the oral cavity: clinicopathologic and immunohistochemical study of 21 cases. Head Neck Pathol. 2009 Jun;3(2):106-15.
4. Ronchi A, Cozzolino I, Zito Marino F, Accardo M, Montella M, Panarese I, et al. Extrapleural solitary fibrous tumor: A distinct entity from pleural solitary fibrous tumor. An update on clinical, molecular and diagnostic features. Ann Diagn Pathol. 2018 Jun;34:142-150.
5. Nunes FB, Sant'Ana MSP, Silva AMB, Agostini M, Silva Canedo NH, de Andrade BAB, et al. Solitary fibrous tumour of the oral cavity: An update. J Oral Pathol Med. 2020 Jan;49(1):14-20.
6. Geramizadeh B, Marzban M, Churg A. Role of Immunohistochemistry in the Diagnosis of Solitary Fibrous Tumor, a Review. Iran J Pathol. 2016 Summer;11(3):195-203.
7. Davanzo B, Emerson RE, Lisy M, Koniaris LG, Kays JK. Solitary fibrous tumor. Transl Gastroenterol Hepatol. 2018 Nov 21;3:94.
8. Rodríguez-Gil Y, González MA, Carcavilla CB, Santamaría JS. Lines of cell differentiation in solitary fibrous tumor: an ultrastructural and immunohistochemical study of 10 cases. Ultrastruct Pathol. 2009 Dec;33(6):274-85.
9. Cummings TJ, Burchette JL, McLendon RE. CD34 and dural fibroblasts: the relationship to solitary fibrous tumor and meningioma. Acta Neuropathol. 2001 Oct;102(4):349-54.
10. Gold JS, Antonescu CR, Hajdu C, Ferrone CR, Hussain M, Lewis JJ, Brennan MF, Coit DG. Clinicopathologic correlates of solitary fibrous tumors. Cancer. 2002 Feb 15;94(4):1057-68.
11. Dungarwalla MM, Barrett AW, Gulati A. Solitary fibrous tumour of the tongue: a series of four cases. J Laryngol Otol. 2017 Sep;131(9):838-841.
12. Doyle LA, Vivero M, Fletcher CD, Mertens F, Hornick JL. Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Mod Pathol. 2014 Mar;27(3):390-5.
13. Schmitz J, Radbruch A. Immunoglobulin class switching. In: Delves PJ, editor. Encyclopedia of Immunology. 2nd ed. Oxford, UK: Elsevier; 1998. p. 1302-1306.
14. Robinson DR, Wu YM, Kalyana-Sundaram S, Cao X, Lonigro RJ, Sung YS, et al. Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet. 2013 Feb;45(2):180-5.
15. Barthelmeß S, Geddert H, Boltze C, Moskalev EA, Bieg M, Sirbu H, et al. Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features. Am J Pathol. 2014 Apr;184(4):1209-1218.
16. Gengler C, Guillou L. Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology. 2006 Jan;48(1):63-74.
17. Bauer JL, Miklos AZ, Thompson LD. Parotid gland solitary fibrous tumor: a case report and clinicopathologic review of 22 cases from the literature. Head Neck Pathol. 2012 Mar;6(1):21-31.
18. Lo Muzio L, Mascolo M, Capodiferro S, Favia G, Maiorano E. Solitary fibrous tumor of the oral cavity: the need for an extensive sampling for a correct diagnosis. J Oral Pathol Med. 2007 Oct;36(9):538-42.
19. Diebold M, Soltermann A, Hottinger S, Haile SR, Bubendorf L, Komminoth P, et al. Prognostic value of MIB-1 proliferation index in solitary fibrous tumors of the pleura implemented in a new score - a multicenter study. Respir Res. 2017 Dec 16;18(1):210.
20. Ridder GJ, Kayser G, Teszler CB, Pfeiffer J. Solitary fibrous tumors in the head and neck: new insights and implications for diagnosis and treatment. Ann Otol Rhinol Laryngol. 2007 Apr;116(4):265-70.
21. Cox DP, Daniels T, Jordan RC. Solitary fibrous tumor of the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jul;110(1):79-84.
| Issue | Vol 22 (Continuously Published Article-Based) | |
| Section | Case Report | |
| DOI | https://doi.org/10.18502/fid.v22i50.20632 | |
| Keywords | ||
| Solitary Fibrous Tumors Lip Pathology Neoplasms | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Noormohammadi R, Khoadei M, Amirian MB, Rafieya S. Solitary Fibrous Tumor of the Lower Lip; A Rare Case Report. Front Dent. 2026;22.
