Frontiers in Dentistry (FID)  is the first Iranian dental journal in English. FID is an Open Access, Peer-Reviewed  journal published by Dental Research Center (DRC) of Tehran University of Medical Sciences which is a dynamic, rapidly growing research center.

The Journal aims to publish novel and high quality relevant information written by peers to researchers and readers involved in all fields of dentistry, oral health sciences and related interdisciplinaries, strives to keep pace with the rapid growth of publications, and move on to the edge of knowledge in this field.

Frontiers in Dentistry encourages submission from General dentists, dental specialists, clinicians, students and postgraduate students of dentistry, as well as researchers and academic members who do research in the field of dentistry and oral health sciences. The journal supports the following types of articles:

  • Original/Research Article
  • Systematic Review/Meta-Analysis
  • Reports including Technical Reports and Case Reports
  • Letter to the Editor

Announcements

Happy Persian New Year 1402

2023-03-19

HAPPY NOWRUZ!!

Nowruz is the Persian new year and marks the beginning of spring and revival of nature. It means “New Day” in Farsi and it is the first day of the month of Farvardin (March 21st) in the Persian calendar.

On behalf of the Editorial Office of Frontiers in Dentistry we wish all our readers, contributors, authors and reviewers a HAPPY NOWRUZ and extend our sincere gratitude to all those who helped make this Journal a success. May you have a great year filled with prosperity and joy.

Read more about Happy Persian New Year 1402

Current Issue

Vol 22 (Continuously Published Article-Based)

Original Article

  • Evaluation of Pentraxin-3 and Interleukin-6 Levels in Serum and Gingival Crevicular Fluid in Patients with Generalized Periodontitis and Periodontal Health Controls before and after Scaling and Root Planing
    Siamak Yaghobee , Sadegh Hasannia , Fatemeh Hamidzadeh , Saman Valadan Tahbaz , Rojin Shahmohammadi , Farzaneh Poursafar
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    Abstract

    Objectives: Pentraxin-3 (PTX3) and interleukin-6 (IL-6) are two of the most important inflammatory cytokines produced by cells in periodontal tissues. The present study aims to evaluate the levels of PTX3 and IL-6 in serum and gingival crevicular fluid (GCF) in patients with generalized periodontitis stages II and III, grades A and B, and periodontal health individuals before and after scaling and root planing (SRP).

    Materials and Methods: In this study, 22 patients with periodontitis (12 males and 10 females) and 22 periodontal health controls (11 males and 11 females) were selected. All patients underwent full-mouth SRP. Serum and GCF samples were collected before and one month after SRP. PTX3 and IL-6 levels in serum and GCF samples were evaluated by enzyme-linked immunosorbent assay. Data analysis was performed using Mann-Whitney U and Wilcoxon tests (P<0.05).

    Results: Serum levels of PTX3 were significantly higher in the periodontitis group than the controls (P<0.05). GCF PTX3 levels and serum and GCF IL-6 levels were not significantly different between the groups. Furthermore, this study did not show any significant changes in the levels of these cytokines before and after SRP.

    Conclusion: Among the studied cytokines and media, only serum PTX3 levels showed a significant difference between periodontitis patients and healthy controls and could serve as a diagnostic marker of periodontal inflammation. SRP did not affect the levels of these cytokines, suggesting that other inflammatory factors may be involved in disease process. However, additional longitudinal prospective studies are needed to confirm these results.

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